Monday, July 29, 2024

Familial loss accelerates biological aging?


This fascinating study in JAMA Network examines how the loss of a family member may impact one's rate of biological aging:

"We found that adults with a history of loss had higher biological ages than those without such experiences. More losses were associated with older biological age. These findings suggest that loss can accelerate biological aging even before midlife and frequency of losses may compound this, potentially leading to earlier chronic diseases and mortality. "

Cheers,
Colin

Monday, July 22, 2024

Life Expectancy in 2100

 


source  

Cheers, 

Colin

Sunday, July 21, 2024

Inhibition of Protein IL-11 = Increased healthspan?


Nature news has this story about a recent study (published here) of a drug that blocks inflammation (protein IL-11) in mice, resulting in increased healthy lifespan.  A sample from the news item: 

A protein that promotes inflammation could hold the key to a longer, healthier life. Blocking the protein, called IL-11, in middle-aged mice boosted metabolism, reduced frailty and increased lifespan by about 25%.

Although a research team tested for these health effects only in mice, IL-11 and its molecular partners — which include chemical messengers for the immune system called interleukins — also exist in humans. And drug candidates that block IL-11 are already in human trials against cancer and fibrosis, a condition associated with ageing in which scar tissue replaces healthy tissue.

Cheers, 

Colin

Friday, July 12, 2024

Study on Ageism and Social Media


There is an interesting (and timely, given the current state of US politics) study posted in JAGS on social media discourse on ageism, sexism, and racism.  A sample from the findings: 

This study provides empirical support that ageism is one of the least discussed forms of inequality. Furthermore, unlike instances of racism and sexism, which often trigger public outrage and large-scale online activism, instances of ageism rarely precipitate spikes in Twitter activity. This signifies that ageism is a less visible form of discrimination than racism and sexism. Our results also suggest that spikes in Twitter activity for ageism are likely driven by a particular subset of users, namely academics and policymakers with a keen interest in gerontology.

Cheers,

Colin

Wednesday, July 10, 2024

The Demise of Two Prominent Journals in Political Philosophy?


Over the past few months I have read the news, in various social media posts, that the future of two major journals in political philosophy are in jeopardy- Philosophy and Public Affairs and the Journal of Political Philosophy.  

These two journals are among the most influential and prominent for mainstream topics/debates in political philosophy.  So I admit I was very shocked and saddened to learn of their apparent demise.  I am an outsider to the inner circle of both journals, so I do not know exactly what their future fates are and the reasons for this unfortunate development.  It is not clear to me that the journals are ending, only that the editors/ editorial teams of both journals have left with intentions to create open access versions of the journals.  I gather, again from the scant information I have read online (which I suspect is only part of the story), that this occurred because of disagreements/ challenges of working with the publisher. 

Many years ago I decided to write and engage with a readership outside the scope of both of these journals, in part because I did not find the core of the field particularly engaging or interesting and so I sought out other venues/ interlocutors for my research and intellectual development.  But I had hoped both journals would flourish, and perhaps evolve and develop in terms of both scope and interdisciplinary engagement.  It can take many decades to build a journal's reputation, and both of these journals had a significant degree of respect among scholars outside of philosophy (e.g. in both law and political science).  Perhaps new open access versions of the journals will inherit the reputable legacies of their predecessors.  The resigning editors/editorial boards seem to think so.  But I admit I am less optimistic, and to be honest I find it problematic that the future of the field has been dramatically altered by only a handful of scholars.  I watched a similar issue arise with the journal Aging Cell a few years back, when the editorial team left to create the new online journal Aging Biology (though Aging Cell continued).

I can imagine the frustration and angst of junior scholars hoping to go up for tenure in a few years who will have published articles over the past few years that are now placed in potentially defunct journals. Or those who may publish future work in relevantly unknown/new open access journals, on the gamble that those journals will be sustained over time and achieve a high reputation.  These junior scholars will face the additional stress of trying to convince deans and provosts that these publication venues are highly reputable publication venues for their research, despite being defunct/ new.  The handful of scholars who resigned from the editorial boards of course are all tenured and gainfully employed, and so can weather the storm of this kind of professional uncertainty more easily than those trying to get established in the field.  So I believe these developments could adversely impact both recruitment into the field, as well as mudding the indicators of the paths to success through the early stages of establishing oneself in the field.    

And my larger worry is that these developments threaten to further marginalize the field within academia.  A decade or so from now a clearer picture of the impact of these changes on the discipline should be apparent.  But until then I guess we cross our fingers and hope things work out!

Cheers, 

Colin