Sunday, July 21, 2024

Inhibition of Protein IL-11 = Increased healthspan?


Nature news has this story about a recent study (published here) of a drug that blocks inflammation (protein IL-11) in mice, resulting in increased healthy lifespan.  A sample from the news item: 

A protein that promotes inflammation could hold the key to a longer, healthier life. Blocking the protein, called IL-11, in middle-aged mice boosted metabolism, reduced frailty and increased lifespan by about 25%.

Although a research team tested for these health effects only in mice, IL-11 and its molecular partners — which include chemical messengers for the immune system called interleukins — also exist in humans. And drug candidates that block IL-11 are already in human trials against cancer and fibrosis, a condition associated with ageing in which scar tissue replaces healthy tissue.

Cheers, 

Colin