Tuesday, May 13, 2008

Centenarian Prevalence in Okinawa


Okinawa in Japan has among the world's highest reported prevalence of centenarians. And for scientists interested in human longevity this makes the population in Okinawa very interesting and important.

Yet verifying centenarian prevalence is of course difficult for a variety of reasons. But this article in the latest issue of The Journals of Gerontology Series A: Biological Sciences and Medical Sciences makes the case for validating the centenarian prevalence in Okinawa. Here is a sample from the study:

THE National Institute on Aging (NIA) Advisory Panel on Exceptional Longevity (APEL) (1) and the NIA strategic plan (2) have identified healthy aging as a research priority. However, few individuals survive to exceptional ages in robust health. Centenarians possess genetic and/or environmental attributes that allow them to survive to exceptional ages, and many appear to delay or avoid major age-related diseases and disability (3,4). Okinawa, the southwesternmost prefecture of Japan, is an isolated island population that possesses the longest life expectancy and the lowest risk for major age-related, chronic diseases in Japan, the world's longest-lived country (5–7). Geriatric studies of the older population also demonstrate that Okinawans appear to have high physical and cognitive function at older ages (3,8,9). Consistent with these studies, the Japanese government's Annual Centenarian Report ranks Okinawa as having the highest prevalence of centenarians of any prefecture within Japan (10). Therefore, the Okinawan population may be important for further study of genetic and/or environmental traits that lead to exceptional longevity, including longevity with good health. However, studies of exceptionally aged persons require precise definitions of phenotypes, the most important of which is accurate age for the study participant.

.... As the world's population ages, increased research emphasis has been placed on identification of populations with high prevalence of healthy, older individuals for the study of healthy aging and exceptional longevity (1,2). Precise phenotyping, particularly accurate age, is required. This is especially important for genetic studies of human longevity; therefore, age validation has become an important part of such research (7,15,16,23,33,34). Thus, the purported high prevalence of centenarians in Okinawa has been a subject of keen interest and some controversy.

.... We hypothesize that the Okinawa longevity phenomenon is due to a number of factors that have coalesced to decrease the risk for both age-associated disease and mortality among older people. For example, there appear to be important genetic aspects to Okinawan longevity (7,37,38) that merit further investigation. The traditional diet, low in calories but high in nutrition, may have also led to a population-wide caloric restriction phenomenon, among other dietary and lifestyle factors (8,39–41). A superior public health system and other social and psychological factors may have also contributed to this longevity phenomenon (32). These factors deserve further investigation. Discovering the basis for the longevity advantage in Okinawa may have important potential implications for human health.

.... Centenarians are a valuable resource for the study of factors associated with exceptional longevity and healthy aging (7). However, most centenarian studies take place in European or North American countries, and few studies include minorities. As an ethnically distinct, isolated population of Japan with a very high prevalence of centenarians, a long life expectancy, and a highly functional elderly population, the Okinawans are an important population for studies of the genetic and environmental correlates of exceptional longevity. Further study of this population is warranted.


Cheers,
Colin

Monday, May 12, 2008

Are You Guilty of Gerontologiphobia?






Ask yourself the following questions:


(a) Do you think it would be a good thing if fewer people died of cancer?

(b) Do you think it would be a good thing if fewer people died of heart disease?

(c) Do you think it would be a good thing if fewer people died of diabetes?

(d) Do you think it would be a good thing if fewer people died of infection?

(e) Do you think it would be a good thing if fewer people died of bone fracture?


Now ask yourself this:

(f) Do you think it would be a good thing if all of the above (a-e) could be accomplished?

I suspect most people would say “yes!”; that it would be wonderful to accomplish such laudable goals.

What if I told you that we could possibly achieve these goals but it would take some public funding, some time and some potential risks?

Assuming the money, time and risks were not too substantial, you probably would say “Let’s go for it!”

But what if I said this could possibly be accomplished by manipulating human longevity? ………..errrhhh… I hear the brakes screeching!

This last step will no doubt result in my losing many people who were, up till that stage of things, on board with the aspirations I was outlining.

So let’s see why people are likely to protest achieving these goals by manipulating longevity.

Is it the costs? Well, aging research is actually grossly under funded. As Jay Olshansky et. al. point out in this excellent paper, in 2006 the NIH was funded at $28 billion and yet less than 0.1% of that funding was spent on understanding the biology of aging and how it predisposes us to a vast array of costly diseases and disorders expressed at later ages. So we are spending billions pursuing each of (a) through (e) and yet very little on something that might accomplish all of these things at once (f). That doesn’t make sense does it?

Is it the time scale? Maybe people think retarding aging is something that would only happen, if ever, in the very distant future. "We shouldn’t waste our time pursuing interventions that will likely benefit people in 500 years when there are so many problems to deal with now" one might argue. Again, this response is not persuasive given that (1) aging research (despite being poorly funded) is rapidly progressing and the time scale for real tangible benefits- especially if we invested sufficient funds- is much smaller than most people would expect. Recall this post, the first anti-aging molecule is going to be tested in humans this year! So the science is much further along than most people realize.

And (2) given the magnitude of the benefits at stake in (f), our attitude towards the time scale issue needs to be consistent. Few people are willing to abandon cancer research or research into heart disease just because it might take some time to make serious headway on these diseases. Given that retarding aging could accomplish much more than eliminating any one disease could accomplish, it doesn’t make sense to single out the science of longevity for disparagement.

Is it the risk? Perhaps some believe that you could never safely apply an anti-aging intervention. Of course one must bear in mind that nothing in life is “risk free”. All the things in (a) – (e) have risks for us (indeed they kill millions every year). Would it be better to remain in the biological “status quo” of being intrinsically vulnerable to the diseases of aging versus pursuing an intervention that could reduce these risks (even if such an intervention had some risk of harm itself)? The devil is really in the details. I agree that how we could sensibly manage the risks in such a case is a challenging issue (especially if the intervention is to be pursued early in life), but it is not unprecedented. Vaccines, for example, have some risks associated with them yet their benefits far outweigh those risks. And the same applies for almost every medical intervention. So it is not rational to pick out the modulation of the aging process for special attention in this regard. [for more on my thoughts on this topic, see this article]

I recently read this excellent article by Richard Miller. He posits nine reasons for the current neglect of aging research. These range from scientific obstacles- like the time it takes to complete aging experiments in mammals- to political obstacles like the scarcity of lobbyists for basic aging research (compared to the lobbies for specific diseases like cancer or Alzheimer’s). One major obstacle that Miller specifically draws attention to as an impediment to manipulating longevity is what he calls “gerontologiphobia”. He describes this as follows:

There is an irrational public predisposition to regard research on specific late-life diseases as marvelous but to regard research on aging, and thus all late-life diseases together, as a public menace bound to produce a world filled with nonproductive, chronically disabled, unhappy senior citizens consuming more resources than they produce. No one who speaks in public about longevity research goes very far before encountering the widespread belief that research on extending the life span is unethical, because it will create a world with too many old people and not enough room for young folks.


Are you guilty of gerontologiphobia? This is a serious question we must all consider. For our attitudes towards aging and the science of longevity could stifle one of the most significant medical breakthroughs we could make this century. Retarding aging would significantly improve the health prospects of all persons who are susceptible to aging.

Cheers,
Colin

Friday, May 09, 2008

EMBO Reports Article on Aging

My article "A Tale of Two Strategies: The Moral Imperative to Tackle Ageing" has been accepted for publication in Nature's EMBO Reports. This paper should be published in the next few months. Here is a brief sample:

Research into ageing is a fascinating field of scientific study, not least because it addresses a topic that, sooner or later, affects everyone. At the same time, the science itself is rapidly progressing with a constant flow of publications that help to elucidate the numerous causes of ageing, such as DNA damage, the shortening of telomeres, oxidation processes in the cell, and so on. Based on this wealth of information, scientists have begun to explore interventions that could modify the biological processes that lead to ageing, thus creating opportunities for people to live longer and healthier lives. However, the biology of ageing is very complex and involves many molecular and physiological processes that, though they eventually lead to ageing, still have important functional roles. It is therefore not surprising that, while scientists basically agree that ageing itself is not immutable, they continue to disagree significantly as to what might constitute the most promising strategy for retarding human ageing. Such scientific disagreement is, of course, neither novel nor specific to ageing-related research—it rightly permeates all branches of scientific inquiry.

But there is another disagreement that currently embroils researchers studying ageing, which is a debate about how they ought to frame the moral imperative to retard human ageing. Is ageing actually a disease? If so, should we invest more public money to find a cure for it, or are the medical interventions that could retard ageing best classified as ‘enhancements’ rather than therapies? Does this really matter and, in any case, do the answers to these questions have an impact on the prioritization of research into human ageing?

Cheers,
Colin

Monday, May 05, 2008

Precision vs Proportionality: The Future Direction of Political Philosophy


*Originally posted Jan. 2008*

I believe that contemporary political philosophy is at an important crossroads, and this makes it a very interesting and exciting time to be working in the field. In this post I will elaborate a bit on why I believe this to be the case.

In many respects this post brings together some disparate thoughts I have posted before. It is really Part 2 to my earlier entry “What Justice Requires “Many-Things-Considered”". And this post was also partly motivated by the interesting exchange that took place over at Crooked Timber a while back. Here I offer some more specific thoughts on the methodological issues that arise when we aspire to develop, and assess, theories of distributive justice.

What does justice demand of us, as both individuals and societies? One could attempt to answer this question by developing normative analyses at varying levels of abstraction, with varying degrees of precision and detail. I’ll return to this issue shortly, but first there are some preliminaries that need to be addressed.

When contemporary philosophers approach the issue of distributive justice they begin from *somewhere* (no one’s ideas exist in a vacuum), whether it be a particular liberal, egalitarian, communitarian, feminist or multicultural framework. One begins with certain theoretical commitments- like equality, freedom, inclusion, etc.- and perhaps an alliance to a particular philosophical theory (e.g. consequentialism, Rawlsian liberalism, equality of welfare, etc.)

With so many interesting and varied theories of justice on offer, who wants to spend their career trying to re-invent the wheel by developing a new theory or approach?! (note: of course the greatest scholars of the past 3 or 4 decades are, at least in my opinion, the ones who tried to do precisely this!) It's so much easier to simply begin with one of the theories already out there (whichever one takes your fancy) and then build on it, refining the theory in new and interesting ways. This is, I believe, what has mostly occurred over the past few decades in debates in political philosophy.

But suppose for a moment that we did not have the barrage of theories on offer that we actually do have. Suppose we really were starting from scratch. I know this might be a bit hard to envision but lets just see where this goes. Sometimes it is helpful to try to get some distance from the projects that preoccupy most of our thoughts and energies.

So, now that we have wiped the slate clean, suppose someone comes along and says they have what they consider to be a pretty good theory of justice. And they think that, once you hear the details of their theory, you too will be convinced that it is a good theory.

Now if we stop things there, before you hear any of the details of the potential theory on offer, lets consider first the initial expectations you have concerning what a theory is suppose to deliver. What do we want from a theory of justice?
Philosophers will have different answers to this question. And I believe the expectations we have are deeply influenced by what we think of our actual societies (e.g. their virtues and vices) and the kind of “ideal” society that we could achieve. So liberals will want a theory of justice that takes liberty seriously. Egalitarians want a theory that takes equality seriously. Feminists want a theory that takes gender seriously... You get the picture.

Now some of these convictions will reflect ideological differences. But they also reflect different perceptions of the empirical realities facing one’s society. For example, that more could be done to reduce economic inequality and improve the life prospects of the poor. Or that the government could do more to ensure that the family is not an institution that entrenches patriarchy (and that it could do this without being oppressive). Thus our expectations concerning what we want from a theory of justice will be deeply influenced by a mixture of normative and empirical considerations.

Enormous assumptions are frequently made concerning what the state can and cannot successfully do. But these empirical assumptions are seldom made explicit. This is, in my opinion, one of the biggest problems with the state of contemporary political philosophy. We have yet to take seriously what Adrian Vermeule calls “the institutional turn”. I’ll link this point to the general question raised earlier towards the end of this post.

But lets return now to my general methodological question: what do we want from a theory of justice? How would we know if the theory someone is offering us is real gold or just fool’s gold? Two of the richest and most influential (and I think probably among the greatest works in political philosophy in the 20th Century) theories of justice shed light on these methodological issues- Rawls’s A Theory of Justice (1971) and Gauthier’s Morals by Agreement (1986).

For Rawls, the main criterion for success is reflective equilibrium. And for Gauthier, the criterion is that a theory must be premised on rational self-interest.

So the Rawlsian believes you have a good account of justice when it coheres with your considered judgments and the Hobbesian contractarian believes you have a good account of morality/justice when you can convince the moral skeptic that they too should be just.

Rawls’s approach captures both motivational and guiding requirements. His contractarian account of justice (like the original position) is premised upon moral sentiments he believes no reasonable person could reject (e.g. impartiality, the equality of all persons). And he also believes that the conclusions yielded by his theory are a good guide for liberal democracies (or at least they are a better guide than its main rival utilitarianism).

Although Gauthier presents his approach as primarily being concerned with providing a rational foundation for morality, he also brings in moral premises that make his conclusions more palatable (e.g. the Lockean proviso), thus permitting him to offer some guiding prescriptions.

What would the ideal Rawlsian and Gauthierian society look like? Well, for Rawls it is a society that satisfies his three serially ordered principles of justice. See my post “Are You a Fully Fledged Rawlsian?” to see if you agree with Rawls’s basic prescriptions. With respect to Gauthier’s theory, well, that’s even harder to determine. While his principle of minimax relative concession might make some sense in two-person examples, how one goes about applying it to the real world has always puzzled me. And other parts of Gauthier’s theory, like his commitment to the rough equality clause, leads his theory to some very counterintuitive results (e.g. what Allen Buchanan calls the “reciprocity thesis”).

OK, so let’s return to the motivation and guiding requirements. These two requirements remind us of what a theory of justice is primarily for: it’s for us! I don’t mean just you and me. I mean for us as a society. Those of us living in the “here and now”- in the societies we find ourselves, with the pressing moral and practical dilemmas that face us. It is a theory for the biological, temporal, social beings we are. We don’t want a theory of justice for people who might live on Mars in 10 000 years. Or a theory for beings that have a very different biology than ours (e.g. beings that do not need to eat to be nourished, that are not susceptible to disease and disability). We are not interested in what a theory might look like for beings that did not progress through the different life cycles that real, temporal, finite beings progress through. (For an account of what we do want, rather than what we don’t want, see “Taking People For What They Really Are”)

As the example of Rawls and Gauthier illustrate, the motivation/guiding requirements of justice could be (and have been) spun in a number of different ways. Keeping things a level of generality then, we can ask: how adequate are these criteria for a philosophical account of justice? Of course much depends on what one takes the *philosophical* part to mean. It can be cut two different ways, depending on what one takes “philosophy” to mean.

The first way is to view the philosopher as what I will call a “conceptual surgeon”. This means the philosopher is someone who views concepts (like equality) as something they need to dissect, analyze, then refine and polish before churning out a pristine and comprehensive account of what justice requires.

The second way is to view the political philosopher as someone who longs for *wisdom* (see this post) concerning how we ought to live collectively. Can the conceptual surgeon help impart wisdom? To some degree I think the answer is “yes”. Take Isaiah Berlin’s masterful “Two Concepts of Liberty”. If one wants to create a free polity then it is imperative that one gets clear on what freedom actually means. Pursuing negative or positive freedom will take one in different directions. And so achieving some conceptual clarity will help one on their journey towards creating a free society.

But while it is important to recognize that some conceptual clarify is necessary and useful, it is also important to realize that conceptual surgery has its limits. If we invest most of our intellectual energies into conceptual surgery then we risk missing the boat.

To push the surgeon analogy further- while some minor conceptual surgery can be therapeutic, if one goes too far they run the risk of doing more harm than good. Like a skilled surgeon, the political philosopher should not subject her patient to unnecessary surgery. I believe that a good deal of what currently passes for political philosophy is in fact unnecessary surgery; procedures that will not increase the health prospects of the patient. In fact, such conceptual surgery can actually be harmful to the patient as we end up spending all our time and energies on the intricacies of our conceptual surgery and thus miss other obvious things that could be beneficial to the patient (like sterilizing our utensils, checking the patient’s blood pressure, etc.). OK, I don’t want to take the medical analogy too far. But hopefully you get my point!

So if conceptual surgery is part, but *only* part, of what is involved in being a good political philosopher, what else do we need if we hope to create and impart wisdom? (at least the kind of wisdom that a political philosopher could hope to achieve and impart). This takes me to the second theme in my title: proportionality. What the philosopher should really strive for, if they hope to convey some wisdom, is a sense of what the “big picture” perspective of the moral and political landscape looks like. And to do this we must take seriously the issue of proportions. And this is something that conceptual surgery cannot provide. Let me give you two examples, from different ends of the political spectrum, concerning how conceptual rigor can stifle proportionality (and thus wisdom).

My two examples come from two of the most influential philosophers from the past 30 years- Robert Nozick and G.A. Cohen. Nozick’s entitlement theory of justice contains three principles- the principle of transfer, the principle of just initial acquisition and the principle of rectification. The bulk of Anarchy, State and Utopia concerns the first two principles. So Nozick introduces examples like the “eye lottery” and his famous Wilt Chamberlain example to illustrate his point that “taxation is on a moral par with forced labour”. But once one gets to the principle of rectification, and one reflects on how wealth and income have, over human history, been acquired and transferred, one realizes that they must qualify Nozick’s motto so that it reads “taxation is on a moral par with forced labour…if and only if no considerations of injustice could apply to justify such taxation”.

Given the actual history of the world it is puzzling why Nozick did not spend the bulk of his book on rectification, and then just have a small chapter entitled “Why Libertarianism is Required After You Rectify All Past Injustice”. So Nozick’s account of justice gets the proportions wrong. The principles of transfer and just initial acquisition are not vital components of a theory of justice for the world as it actually is. And once he gets the proportions wrong, Nozick is unable to generate any sage prescriptions concerning what constitutes a just government.

The “big picture” story of justice is, according to Nozickians, “get your hands off my income!”. It is not “Hey, let’s rectify past injustices!”. Clarifying what the requirements of self-ownership are in the ideal scenario did not help right libertarians figure out what justice required in the real world. Thus Nozick’s theory was wisdom-impairing rather than wisdom-enhancing.

OK, now an example from the other end of the spectrum- G.A. Cohen’s egalitarianism. I’ve posted my objections to luck egalitarianism before, so I’ll keep this brief. My discontents with luck egalitarianism were reaffirmed after hearing Cohen’s recent interview here. At one stage in the interview the discussion focuses on the central insight of luck egalitarianism- that inequalities we are not responsible for should be mitigated, but those we are responsible for should be tolerated. When the presenter asks Cohen to elaborate on the latter, Cohen says “nothing is ever merely the result human responsible action”. This empirical fact is, in my view, more than a sufficient reason to reject luck egalitarianism. For it shows that the theory has nothing interesting to say about the real world. Given that no inequalities satisfy the Cohenian account of “chosen inequalities”, then one does not need to be a luck egalitarian.

Now of course one might say that there could be a counterfactual society where such inequalities could arise. And thus it is imperative that we clarify precisely what we mean by “egalitarian”. But why should we want to do that? The fervor that many egalitarians get themselves worked up into in this respect reminds me of the medieval theological disputes concerning how many angels could dance on the head of a pin. I can’t see what the point of resolving such a dispute is, especially considering that Cohen himself admits that the second component of luck egalitarianism does not apply in the real world. So I think this is another example of how conceptual surgery can distort proportions and thus impair wisdom. In the “big picture” of things, justice does not require us to ensure we do not compensate chosen inequalities as such inequalities cannot be said to exist in the first place! The real action to be had is not on the site of precision, it is on the site proportions. And luck egalitarianism is of no real help on that front.

What does all this tell us? Lets return now to my initial question: What does justice demand of us, as both individuals and societies? The conceptual surgeons would have us believe that we could capture the requirements of justice in a nifty slogan like “Liberty upsets Patterns!”. But such mottos do not convey wisdom. If forced to come up with a slogan I suppose mine would be “Justice is about proportionality”. This is not a novel suggestion, as it goes all the way back to insights made by Aristotle. And I guess I long for a return to seeing philosophy as an activity primarily concerned with phronesis. Of course I believe precision does have a role to play here. For there is lots of work to be done in terms of clarifying what the stakes are that are in need of balancing. And so I would like to see the conceptual surgeons investing more of their time tackling the notion of proportionality. Doing this will shift us away from trying to win a “first best conceptualism” debate and propel us towards seriously engaging with the empirical and the “institutional turn”.

So the title of this post- “Precision Vs Proportionality”-is, at the end of the day, a false dichotomy. We need both. But given how much time political philosophers have spent on precision, it is not surprising that we have messed up on the proportions!

Cheers,
Colin

Friday, May 02, 2008

PLOS Biology Article on Sleep

In a few previous posts I have linked to studies on sleep, like this one, this and this.

The latest issue of PLOS Biology has this article entitled "Why We Sleep: The Temporal Organization of Recovery" by Emmanuel Mignot. Here is a sample:

If sleep does not serve an absolutely vital function, then it is the biggest mistake the evolutionary process has ever made,” Allan Rechtschaffen said. Studies of sleep and sleep deprivation suggest that the functions of sleep include recovery at the cellular, network, and endocrine system levels, energy conservation and ecological adaptations, and a role in learning and synaptic plasticity.

....Sleep is as necessary as water and food, yet it is unclear why it is required and maintained by evolution. Recent work suggests multiple roles, a correlation with synaptic plasticity changes in the brain, and widespread changes in gene expression, not unlike what has been recently discovered in circadian biology. Functional data are however still largely lacking, and studies such as functional genomic screens in model organisms, comparative sleep neuroanatomy through phylogeny, and the study of molecular changes within specific wake, REM sleep, and NREM sleep regulatory systems are needed. The resilience of behavioral sleep in evolution and after experimental manipulations may be secondary to the fact that it is grounded at the molecular, cellular, and network levels.


Cheers,
Colin

Wednesday, April 30, 2008

Risk Alleles for Osteoporosis Identified


The latest issue of The Lancet has this interesting article on a genome-wide association study for osteoporosis and osteoporotic fracture. Here is a sample:

Osteoporosis and its main complication, fragility fractures, incur substantial global morbidity and mortality.1 The public-health burden of this disease is US$17 billion every year in direct expenditure—and this is expected to increase dramatically as populations age.2 Osteoporosis is defined clinically through the measurement of bone mineral density, which remains the single best predictor of primary osteoporotic fractures.3 Bone mineral density is highly heritable, with estimates from a cohort study in the UK of 78% heritability of density at lumbar spine and 84% at femoral neck;4 these figures are consistent with other twin studies.5 Only a few well-replicated studies of candidate genes for osteoporosis have so far emerged,6–8 suggesting that bone mineral density is a complex polygenic trait.5

Genome-wide association studies have been facilitated by the HapMap project, and by recent advances in genome-wide genotyping arrays that provide a high degree of genome coverage.9 We therefore undertook a genome-wide association study to identify genetic loci that influence bone mineral density.

....We have identified genetic variants that decrease bone mineral density and predispose people to osteoporosis and osteoporotic fracture. The increased risk of osteoporotic fracture in people who had both risk alleles was independent of the effect of these alleles on bone mineral density.

....In conclusion, the risk alleles we have identified justifiy further clinical and biological investigations. These SNPs alone are unlikely to change current clinical practice, but as has been shown for other diseases,59 extended panels of several SNP markers could be used in the future, in addition to traditional risk factors, to better identify populations who are at high risk for osteoporotic fractures.

Cheers,
Colin

Tuesday, April 29, 2008

UTLJ Review Article (Now Published)


My paper entitled "The Institutional Theory of Legal Interpretation" is published in the latest issue of The University of Toronto Law Journal. This paper is a review article of Adrian Vermeule's excellent book Judging Under Uncertainty.

It was a real joy reading Vermeule's book. Legal theory has long been dominated by debates concerning the primacy of different high-level conceptual commitments, like democracy and constitutionalism. Vermeule documents the chronic condition of institutional blindness in Anglo-American interpretive theory, covering the contributions of important historical figures — like William Blackstone and Jeremy Bentham — to the most important contemporary contributions, such as the theories of H.L.A Hart, Ronald Dworkin, and Richard Posner. Rather than trying to win a debate concerning "first-best conceptualism", Vermeule makes the case for developing a second-best interpretive theory. Second-best interpretive theories ask how nonideal interpreters of law should proceed in light of widespread disagreement about competing first-best theories and given the institutional constraints and political conditions that actually obtain in the legal system.

There are a lot of important insights Canadian legal theorists can incorporate from Vermeule's institutional theory, especially for the "dialogical model" of judicial review which I am interested in (see here). And Vermeule's concerns parallel many of those I have for political philosophy more generally (esp. theories of distributive justice). I will post some more specific thoughts on these issues later. Here is the abstract of this UTLJ article:

In his provocative and masterly book Judging Under Uncertainty Adrian Vermeule seeks to displace the dominance of what he calls ‘first-best conceptualism’ in legal theory and instead argues that interpretive law needs to take an institutional turn. Vermeule’s focus on the empirical problems of institutional interpretation is a welcome and long overdue contribution to legal theory. Judging Under Uncertainty is an ambitious book and a valuable contribution to legal theory. The book deals exclusively with American law and Vermeule’s institutional approach to legal interpretation takes the existing status quo of the American system as a given. This, one might be tempted to complain, limits the scope and application of the institutional theory advanced by Vermeule. I shall raise some of these concerns towards the end of this review article when I consider some of the insights Canadian jurisprudence could contribute to the development on an institutional theory of legal interpretation (as well as the insights Canadian legal theorists can take from Vermeule’s compelling and important arguments).


Cheers,
Colin